The hosts scraped a 1-0 victory over Caen in their midweek cup game, while Nice eased past fellow top-flight outfit Nimes for a second victory in succession.
Even with numerous changes, Mauricio Pochettino would have expected his PSG side to notch up more than a solitary goal against second-tier Caen, but Moise Kean's 49th-minute winner was all that separated the two teams on the night as the French champions managed to secure a third victory on the trot.
However, one dampening aspect of that midweek defeat was the injury to star man Neymar, who lasted 60 minutes before being scythed down and sustaining an adductor problem, and the ex-Barcelona man will be unable to face his former club in the Champions League next week.
A Neymar-less PSG will have to navigate this weekend's task with their usual defensive solidity if they are to come up trumps, as the 1-0 win at Caen represented their third win and clean sheet in succession in all competitions since that shock defeat to Lorient last month.
Pochettino's PSG have won six of their last seven in the top flight and are not relinquishing their Ligue 1 crown without a fight, but they remain three points behind a rampant Lille outfit at the top of the table, while Lyon's own remarkable winning streak is keeping them just above the champions after 24 matches.
This week's hosts needed no second invitation to stamp their authority on Marseille and take the spoils in the 100th Classique last weekend, with Mauro Icardi and Kylian Mbappe - the latter scoring his 16th league goal of the season - propelling Pochettino's side to victory over their under-performing rivals, but Nice are starting to show a glimmer of hope after their torrid run of late.
An unexpected 3-0 triumph against Angers preceded another three-goal showing at the home of basement side Nimes in the Coupe de France, during which Rony Lopes bagged a brace and Pierre Lees Melou completed the rout as Nice advanced to the next round of the cup with minimal difficulty.
Les Aiglons' dominant victory over Angers was only their third in 14 Ligue 1 outings, and with a 10-point gap now separating this weekend's visitors from the bottom three, any fears of relegation will be quashed if Nice can pick up a few more victories in the coming weeks.
Furthermore, Nice's form on the road is surprisingly strong, as they have lost just two of their last nine away outings in the top flight, but trying to get one over PSG - no matter how many injury problems they have - could be a bridge too far for Les Aiglons.
The champions eased to a 3-0 win at the Allianz Riviera earlier in the campaign, and Nice have not walked away from the capital with all three points since the 2009-10 campaign.
Paris Saint-Germain Ligue 1 form: WWWLWW
Paris Saint-Germain form (all competitions): WWLWWW
Nice Ligue 1 form: DLWLLW
Nice form (all competitions): LWLLWW
PSG revealed on Thursday that Neymar will be sidelined for approximately four weeks with his adductor injury, and Pochettino has also lost another winger in Angel Di Maria to the thigh problem he sustained in Le Classique last Sunday.
Keylor Navas is expected to return in between the sticks against Barcelona but may not be risked here, while Mauro Icardi should demote Kean to the bench despite his winning goal in the Coupe de France.
The absences of Lotomba and Atal means that 20-year-old Andy Pelmard could be trying to keep Mbappe quiet, while the injury-plagued Kasper Dolberg is not available after undergoing an operation for appendicitis.
The French Football Federation are reportedly set to investigate a leaked video involving William Saliba, but Ursea has stressed that the incident is in the past and Nice's player of the month for January is highly unlikely to be dropped.
Paris Saint-Germain possible starting lineup:
Rico; Florenzi, Marquinhos, Kimpembe, Kurzawa; Gueye, Paredes, Draxler; Sarabia, Icardi, Mbappe
Nice possible starting lineup:
Benitez; Pelmard, Saliba, Todibo, Kamara; Thuram, Lees Melou, Boudaoui; Lopes, Maolida, Gouiri
We say: Paris Saint-Germain 2-0 Nice
PSG's infirmary is starting to fill up again at the worst possible time, but the champions should have no problem overcoming a Nice outfit who have flattered to deceive for most of the campaign. The visitors are showing signs of life at long last, but Pochettino's men are expected to have too much firepower for Ursea's side and will look to keep pace with Lille and Lyon with a routine win this weekend.