Granada vs. Man Utd (Thursday, 8.00pm)
The Spanish surprise package dumped Molde out of the tournament to advance to the last eight, whereas Man United overcame AC Milan 2-1 on aggregate in the last 16.
We say: Granada 0-2 Manchester United
United cannot afford to start this game in the same way that they did against Brighton, but confidence cannot be high in the Granada camp after back-to-back league defeats. The hosts have earned their right to be here, although they are afflicted with numerous injuries and the Red Devils are renowned for their impressive performances on the road, so we can only back a comfortable first-leg triumph for Solskjaer's side.
Arsenal vs. Slavia Prague (Thursday, 8.00pm)
The Gunners scraped a 3-2 aggregate victory over Olympiacos to book their spot in the last eight, whereas Slavia Prague dumped Rangers out of the tournament, but that tie was overshadowed by controversy.
We say: Arsenal 2-1 Slavia Prague
Arsenal will undoubtedly want to do right by their former player Kamara this week, although nothing has been proven yet, and Arteta knows that it is Europa League or bust given their torrid league fortunes. The visitors command respect given their remarkable unbeaten run, but the Gunners will be out for blood against a ravaged Slavia defence and their teenage goalkeeper, so we are backing Arsenal to claim a narrow first-leg win, albeit without a clean sheet once again.
Ajax vs. Roma (Thursday, 8.00pm)
The clubs convene at the Johan Cruijff ArenA, seeking an advantage to take into next week's return in Rome - with the hosts 90 minutes away from a record-equalling 11th successive home win in the competition and the visitors having won all four matches in this year's knockout phase.
We say: Ajax 2-2 Roma
The final representatives of their respective nations in Europe this season are both committed to attacking principles and could potentially serve up a feast of football during the next week.
Roma's deficiencies at the back have not been helped by a rotating cast of defenders visiting the physio's table, so they will find it tough to resist free-scoring Ajax - particularly away from their Stadio Olimpico stronghold.
While the hosts' air of invincibility on home turf may be threatened by the Italian side's incisive incursions in the final third, a score draw would set up a mouthwatering return leg in Rome.
Dinamo Zagreb vs. Villarreal (Thursday, 8.00pm)
We say: Dinamo Zagreb 0-1 Villarreal
Zagreb pulled off an incredible upset in the last round and have won eight games in a row on home soil in all competitions, four of those in Europe.
However, Villarreal have won nine and drawn one of their 10 European games this term and are experienced when it comes to this stage of the tournament, so we are backing them to take an advantage into the second leg.