Martinez's injury concerns do not end there, as midfielder Luis Milla is nursing a hamstring problem and not ready to return just yet, so Maxime Gonalons could be partnered by Yan Eteki for the first leg.
Further up the pitch, Manchester City loanee Yangel Herrera will relish the opportunity to get one over his parent club's arch rivals, and another Premier League loanee in Kenedy, who joined on a temporary basis from Chelsea in the summer, is in line to start out wide.
With Colombian forward Luis Suarez also nursing a muscular problem, 35-year-old Roberto Soldado should lead the line for Granada this week, although a man three years his senior in Jorge Molina is another option for the hosts.
Granada possible starting lineup:
Silva; Vallejo, Duarte, Sanchez, Diaz; Gonalons, Eteki; Kenedy, Herrera, Machis; Soldado