The Reds are still unbeaten in the Premier League this season and go into the weekend sitting only two points adrift of leaders Manchester City.
Liverpool are also enjoying their longest ever unbeaten streak against Everton and have not lost a home Merseyside derby since 1999, but Everton will be encouraged by their own recent form.
Here, Sports Mole looks at how Jurgen Klopp could line his side up at Anfield.
Liverpool will be without captain Jordan Henderson for the derby following his red card against Watford last weekend, which increases the likelihood of James Milner starting.
There are growing calls for Klopp to hand more regular football to Fabinho and in particular Naby Keita, but the German boss could opt for previous derby experience in this match which would give Milner the edge.
Many of Liverpool's best performances this season have come in a 4-2-3-1 formation, and after the 4-3-3 midfield trio struggled again in the Champions League on Wednesday Klopp is expected to revert to that system this weekend.