The Toffees have not won an away derby since 1999 and are without a win of any kind in this fixture since 2010 - a 17-match run which is their longest ever spell without victory against Liverpool.
Marco Silva could become the first Everton manager in history to win his first Merseyside derby at Anfield, and he will be buoyed by a recent run of form which has seen his side lose just one of their last seven league games.
Here, Sports Mole looks at how he could set Everton out for the short trip across Stanley Park.
Silva is blessed with a clean bill of health for this weekend's match as James McCarthy and Jonjoe Kenny - neither of whom would be involved in his strongest XI - are the only doubts.
Should that be the case then there will be five derby debutants in Everton's ranks, with Bernard, Lucas Digne and Yerry Mina joining Gomes and Richarlison in getting their first taste of the famous fixture.