Genoa vs. Atalanta (Saturday, 2.00pm)
While Gian Piero Gasperini's side remain on course for a best-ever league finish after back-to-back wins, the Grifone ensured their Serie A survival with midweek success in Bologna.
We say: Genoa 1-2 Atalanta BC
Atalanta's momentum surely cannot be stopped by Genoa on Saturday, as the Nerazzurri's high-energy team show no signs of slowing at the end of a long and arduous season.
Coming into what could be an historic seven days for the Bergamo club, the visitors will take care of business against a home side with little left to play for.
Spezia vs. Torino (Saturday, 2.00pm)
Il Toro must quickly bounce back from a shocking 7-0 defeat to Milan, while a haul of just three points from their last six games has seen the hosts sink to within four points of the drop zone.
We say: Spezia 1-1 Torino
A point apiece serves the cause of either side, with Torino looking to stabilise after Wednesday night's horror show and their hosts seeking to sneak over the line to secure their future at the elite level.
Neither defence is watertight, however, so expect there to be some thrills, spills and costly errors in the mix at the Picco, as the spoils are ultimately shared.
Juventus vs. Inter Milan (Saturday, 5.00pm)
While the Nerazzurri will seek to seal a league double over their Turin rivals and confirm their current supremacy, Juve simply must win to stay in the hunt for a return to the Champions League next season.
We say: Juventus 1-2 Inter Milan
Inter will simply not let up, as their clear-eyed and confident squad approach the game that brings Italy to a standstill with the mere matter of pride and prestige left to play for.
Therefore, a nervous and often disjointed Juventus may be found wanting again - though signs that Paulo Dybala may be belatedly stirring into life mean that the visitors' back line will not go untested - as the Nerazzurri re-assert their authority as Serie A's number one.
Roma vs. Lazio (Saturday, 7.45pm)
While Simone Inzaghi's Biancocelesti are still outsiders in the race for a top-four finish when Serie A reaches its climax next weekend, their bitterest foes have faltered badly of late and could even miss out on continental qualification completely.
We say: Roma 1-1 Lazio
Roma can effectively end Lazio's aspirations of a Champions League return by holding their great rivals to a hard-fought draw on Saturday evening.
Though struggling with injuries and instability arising from the post-season departure of their head coach, the Giallorossi can certainly breach the error-prone Aquile back line at least once and avoid back-to-back Derby defeats.