The Nerazzurri will seek to seal a league double over the side they have just deposed as champions; travelling to Turin with an almost full complement of first-team players available to ex-Juve coach Antonio Conte.
Since their confirmation as champions, Inter have won their two most recent outings by an aggregate score of 8-2, despite an uncharacteristic amount of rotation by their ever-demanding manager.
Conte surprised many by handing rare opportunities to several squad players, such as Roberto Gagliardini, Danilo D'Ambrosio and Matias Vecino, but is expected to revert to a more familiar XI for Saturday's big clash.
Marcelo Brozovic and Nicolo Barella both returned to the midfield in midweek after only appearing as substitutes last weekend and are set to continue, with Vecino, Christian Eriksen and Stefano Sensi contesting the other central spot.
Goalkeeping stalwart Samir Handanovic comes back in after a rest against Roma, with deputy Ionut Radu set to revert to warming the bench, while Stefan de Vrij should replace Andrea Ranocchia at the heart of the defence.
Meanwhile, veteran duo Aleksandr Kolarov and Arturo Vidal are the only men definitely sidelined for Inter, as Vidal is still following an individual training plan as he recovers from a knee injury sustained in March, while Kolarov will start rehabilitation next week, after undergoing surgery to remove a hernia.
Inter Milan possible starting lineup: Handanovic; Skriniar, De Vrij, Bastoni; Hakimi, Barella, Brozovic, Sensi, Perisic; Lukaku, Martinez