The Cottagers finished 19th in the Premier League last season to end a 13-year spell in the top flight and return to the second tier of English football.
They will be hoping for a more successful and less turbulent campaign this time around having gone through three different managers in 2013-14.
The West Londoners certainly enter the new season as one of the favourites to bounce straight back into the Premier League, and owner Shahid Khan has splashed the cash in an effort to help boss Felix Magath.
As with any club being relegated, though, there have been a number of exits, including established names such as John Heitinga, John Arne Riise, Damien Duff, Steve Sidwell, Giorgios Karagounis, Brede Hangeland, Sascha Riether, Pajtim Kasami, Kieran Richardson, David Stockdale and Ashkan Dejagah.
Such a huge turnover in players is bound to have an impact on the squad, and Magath will be desperate to help his new-look side gel quickly in order to keep up with the early pace-setters.
The signs have been good in pre-season, with just one defeat and five victories from their six outings.
Ipswich also go into this season with hopes of promotion, although their most likely route is certainly via the playoffs rather than as one of the league's top two teams.
The Tractor Boys finished four points off the top six last season and showed signs of a possible challenge in the upcoming campaign, particularly if they can keep the likes of David McGoldrick fit this time around.
Former Crystal Palace defender Jonathan Parr could be the man to do that, and he is likely to be one of a number of debutants on show at Portman Road this weekend.
Possible starting lineups
Ipswich: Gerken; Mings, Berra, Chambers, Parr; Bajner, Hyam, Skuse, Wordsworth; Murphy, McGoldrick
Fulham: Bettinelli; Hoogland, Bodurov, Amorebieta, Stafylidis; David, Parker, Eisfeld, Kacaniklic; Dembele, Woodrow
Sports Mole says: 1-2