Aleksandar Mitrovic scored a 94th-minute header as Fulham recorded a 1-0 victory over Swansea on Wednesday night to bounce back from a three-game winless run in the Championship.
The Cottagers are currently third in the table, five points behind second-placed Leeds United and nine points from the leaders West Bromwich Albion, who are well placed to secure a return to the top division.
Fulham are seven points clear of seventh-placed Bristol City, meanwhile, and it is difficult to imagine Scott Parker's side dropping out of promotion contention in the latter stages of the campaign.
In Mitrovic, meanwhile, the Cottagers have arguably the best striker in the second tier. The 25-year-old has scored 23 times in the Championship this term and will fancy his chances of harming Preston this weekend.
Fulham suffered a 2-1 defeat when they travelled to Deepdale earlier this season, but they have only lost one of their last eight matches with Preston in all competitions.
Preston have never played in the Premier League, but there is no question that they are a team to be taken seriously when it comes to the race for promotion this term.
Alex Neil's side are currently sixth in the table, three points clear of seventh-placed Bristol City despite losing two of their last three league matches.
They suffered a 2-0 defeat away to the leaders West Brom on Tuesday night, although three victories from four matches between February 8 and February 22 saw them remain in a strong position in the table.
There is a fascinating race developing when it comes to the playoff positions, and a positive result for Neil's team this weekend would leave them in a strong position ahead of two winnable matches against Queens Park Rangers and Luton Town next month.
Fulham Championship form: WWDLDW
Preston Championship form: DWWLWL
The Cottagers did not pick up any fresh concerns against Swansea last time out, though, and it would therefore not be a surprise to see the same XI sent onto the field.
Fulham possible starting lineup:
Rodak; Odoi, Hector, Ream, Bryan; Cairney, Arter; Cavaleiro, Reid, Knockaert; Mitrovic
Preston possible starting lineup:
Rudd; Clarke, Bauer, Davies, Hughes; Pearson, Browne; Barkhuizen, Johnson, Maguire; Nugent
We say: Fulham 2-0 Preston
There is simply no downplaying the importance of this match to both teams. Fulham are, rightly, the favourites to triumph on Saturday, and we are struggling to look past the hosts in this particular contest.