Meanwhile, the visitors sit in fifth place in the Eredivisie, and they enter the contest in fine form after losing just one of their last six matches.
Utrecht are guaranteed a Europa Conference League playoff place after picking up 46 points from their 32 league games.
Although their spot in the playoffs is assured, Wednesday's hosts will be hoping for home advantage for the second leg of the semi-final, but to do that they must finish in fifth or sixth position.
Fifth place is out of their reach, but they currently sit just one point behind Vitesse Arnhem who occupy sixth spot ahead of the midweek round of fixtures.
At the weekend, Utrecht missed the chance to move above Vitesse Arnhem after Hidde ter Avest's opener was cancelled out by Daishawn Redan, ensuring that the contest with PEC Zwolle ended in a 1-1 draw.
Despite residing in the playoffs, Utrecht's recent form has been underwhelming, with their previous eight matches yielding just one victory and if they are to match last season's sixth-placed finish then they may have to win at least one of their final two fixtures.
Like their hosts, AZ Alkmaar are assured of a playoff place, but their sights are set higher with an automatic qualification spot for the Europa Conference League still possible.
To achieve that goal, Pascal Jansen's side need to move above Twente, who currently occupy fourth position in the Eredivisie.
Despite picking up a point at home against league leaders Ajax on Saturday, AZ Alkmaar may have left the pitch with a sense of disappointment after leading the reigning Dutch champions.
As they look to collect up all three points on Wednesday, the visitors will try to take inspiration from the comfortable 5-1 victory that they picked up against Utrecht in the reverse fixture.
Henk Veerman made his return from injury to feature as a late substitute against Zwolle, and the 31-year-old is set to be joined on the bench by Mimoun Mahi, who is expected to come back into the matchday squad following an injury issue.
Pavlidis will feature in the forward line, and the 23-year-old will be looking to continue his impressive form after scoring four goals in his last five appearances.
FC Utrecht possible starting lineup:
Oelschlagel; Ter Avest, Van Der Hoorn, Janssen, Van Der Kust; Timber, Maher, Gustafson; Van De Streek, Sylla, Douvikas
AZ Alkmaar possible starting lineup:
Vindahl; Sugawara, Chatzidiakos, Martins Indi, Wijndal; Midtsjo, Reijnders, De Wit; Evjen, Karlsson, Pavlidis
We say: FC Utrecht 1-2 AZ Alkmaar
AZ Alkmaar eased to victory in the reverse fixture against Utrecht, and though we expect Wednesday's contest to be closely-fought, we think that the visitors will have too much quality for their hosts.
Our analysis of all available data, including recent performances and player stats, suggests the most likely outcome of this match is a AZ Alkmaar win with a probability of 42.75%. A win for FC Utrecht has a probability of 32.23% and a draw has a probability of 25%.
The most likely scoreline for an AZ Alkmaar win is 0-1 with a probability of 9.14%. The next most likely scorelines for that outcome are 1-2 (8.98%) and 0-2 (6.96%). The likeliest FC Utrecht win is 1-0 (7.74%), while for a drawn scoreline it is 1-1 (11.79%).