That should see forward Enner Valencia return to the side to lead the line, having been absent from the squad for the final World Cup Qualifier before the beginning of the Copa America.
Currently level with Agustin Delgado on 31 goals, Valencia will go in search of a goal to put him ahead and make him the sole lead scorer in the national team's history.
Winger Gonzalo Plata will also hope to come into the starting XI, having found the net off the bench in their recent defeat to Peru.
One of the most exciting players in the Ecuador ranks is Brighton and Hove Albion prospect Moises Caicedo, who offers dynamism and quality at both ends of the pitch at the age of 19.
Ecuador possible starting XI: Dominguez; Perlaza, Arboleda, Arreaga, Estupinan; Plata, Mendez, Caicedo, Carabali; Estrada, Valencia