Norwich vs. Leicester (Friday, 8pm)
Third-placed Leicester City will be looking to get back to winning ways when they head to bottom-of-the-table Norwich City in the Premier League's Friday night fixture.
The Foxes are winless in four matches in all competitions ahead of their trip to Carrow Road, where Norwich have won just once in their last 10 top-flight outings.
We say: Norwich City 0-2 Leicester City
If Norwich are to pull off a great escape of sorts then they quite simply need to start winning games. Leicester have also struggled for wins of late but offered some encouraging signs in their defeat to Man City, so we are backing them to come out on top in Friday's clash.
Brighton vs. Crystal Palace (Saturday, 12.30pm)
The Seagulls have been struggling for form of late and sit just four points clear of the relegation zone, while a win for Palace could see them rise as high as 11th.
We say: Brighton 1-0 Crystal Palace
Brighton have showed signs of improvement in recent weeks and should end their winless run on Saturday. Palace offer little going forward and with key absentees at the back, the Seagulls can sneak a tight win.
Bournemouth vs. Chelsea (Saturday, 3pm)
Meanwhile, Bournemouth welcome the Blues looking to end a run of two successive defeats, an achievement which may ensure that they remain out of the relegation zone.
We say: Bournemouth 2-2 Chelsea
Given Chelsea's defeat at Bayern and their humbling in this fixture last year, Bournemouth will be confident of gaining a result on the South coast. We expect goals aplenty, with the Blues perhaps doing enough in the final third to earn a share of the spoils.
Newcastle vs. Burnley (Saturday, 3pm)
Meanwhile, Burnley make the trip to St James' Park having recorded 13 points from a possible 15, a run which has taken the Clarets into contention for a European place.
We say: Newcastle United 1-2 Burnley
Newcastle need to get back to winning ways as soon as possible, and Bruce will expect a strong performance from his side this weekend. However, we cannot ignore the confidence and fight within the Burnley ranks, something which should take them to victory in the North-East.
West Ham vs. Southampton (Saturday, 3pm)
The Saints make the trip to England's capital sitting 10 points above the bottom three and the same margin behind fourth-placed Chelsea.
We say: West Ham United 1-2 Southampton
Although West Ham will take the positives from their performance at Anfield, we feel that this match is set up for the Saints to hit the Hammers on the break. With that in mind, expect the visitors to claim a narrow victory.
Watford vs. Liverpool (Saturday, 5.30pm)
Just 12 points from claiming the title, Jurgen Klopp's side would set a new Premier League record for consecutive victories should they chalk up a 19th in a row this weekend, but take on a Watford side that ran them close in the reverse fixture at Anfield.
We say: Watford 0-2 Liverpool
Watford put up a decent fight when in poor form during the reverse fixture, but that can perhaps be put down to a new manager bounce which has since deserted them. Liverpool may not have things all their own way, but with a 19th successive Premier League win on the horizon it is impossible to back against Klopp's relentless side.
Everton vs. Man Utd (Sunday, 2pm)
While Everton have the same ambitions, Carlo Ancelotti's side sit in 11th place and five points adrift of their next opponents.
We say: Everton 1-2 Manchester United
While Everton will be motivated to get the better of their North-West rivals, we are backing United to continue their recent form with a hard-fought win. The visitors are capable of keeping yet another shutout, although Everton are scoring plenty of goals under Ancelotti.
Tottenham vs. Wolves (Sunday, 2pm)
Although both teams have ambitions of securing Champions League football, defeat here could leave either outfit closer to mid-table.
We say: Tottenham Hotspur 2-1 Wolverhampton Wanderers
Although Wolves were able to rest players in midweek, we feel that Spurs' extra preparation time could prove crucial here. Mourinho needs a big performance from his players after two straight defeats, and the North Londoners could deliver in front of their own supporters.