Meanwhile, the French side travel to Celtic Park for the first time knowing that a win would be enough to top Group H ahead of AC Milan.
Celtic suffered another disappointing result on Sunday as they had to come from behind to draw 1-1 at home to St Johnstone in the Scottish Premiership.
The Hoops have now won just two of their last 12 matches in all competitions and the pressure is building on manager Neil Lennon to turn their fortunes around.
Despite their poor form, Celtic have publicly backed Lennon this week and have stated that they believe "Neil and his management team are best placed to turn the team's performances around" and that "progress will be reviewed in the new year".
Those comments from the board will have pleased Lennon, giving him more time this month to address the team's problems.
The Hoops' final Europa League match this Thursday is one that Lennon could really do without, as they have already been eliminated from the competition, losing four of their five matches in Group H.
Celtic's only Europa League point this campaign was collected in the 2-2 draw in the reverse fixture against Lille in October, a game that saw them throw away a two-goal lead.
The Hoops have lost three consecutive home matches in the Europa League this season and have never lost four in a row in Europe at Celtic Park.
Les Dogues have lost only one game all season – a 3-2 defeat away at Brest – and are unbeaten from their last five matches in all competitions, however Christophe Galtier's side had drawn four of their last five matches by a 1-1 scoreline prior to their victory against Monaco.
Nevertheless, Lille are just two points behind Paris Saint-Germain at the top of Ligue 1 and face the French champions in just a few weeks' time.
Lille now turn their attention back to the Europa League, where they have already booked their place in the last 32 following a narrow 2-1 victory over Sparta Prague last week.
This will be the French side's first ever European away match in Scotland and a victory at Celtic Park would be enough for Lille to top Group H ahead of AC Milan in second place.
Celtic Europa League form: LDLLL
Celtic form (all competitions): WDLLLD
Lille Europa League form: WDWDW
Lille form (all competitions): LWDDWW
Neil Lennon may decide to rest a few of his key players to keep them fresh for the weekend, as they cannot afford to slip further behind Rangers in the league.
Winger James Forrest is Celtic's only injury concern ahead of Thursday's match.
Xeka, Benjamin Andre, Sven Botman and Domagoj Bradaric are all one booking away from missing their first knockout match, so Christophe Galtier will have some interesting decisions to make as to whether they feature against Celtic.
Midfielder Renato Sanches has not been involved in Lille's previous two matches but could be in line for a return to the side this week.
Burak Yilmaz, who scored twice in the 2-1 win over Sparta Prague, is likely to start up front alongside Canadian Jonathan David.
Celtic possible starting lineup:
Barkas; Abd Elhamed, Bitton, Duffy, Taylor; Brown, Turnbull, Ntcham; Christie, Klimala, Griffiths
Lille possible starting lineup:
Maignan; Djalo, Fonte, Botman, Reinildo; Ikone, Andre, Soumare, Bamba; Yilmaz, David
We say: Celtic 0-2 Lille
Lille have won both of their Europa League away matches in Group H, scoring seven goals in the process. The French side look stronger than their Scottish counterparts, who are likely to rest a few key players, and they should come away with another three points.