Osasuna vs. Celta Vigo (Saturday, 4.00pm)
The visitors are currently 15th in the table, seven points clear of the relegation zone, while Osasuna, who have impressed many with their form this season, occupy 11th.
We say: Osasuna 1-1 Celta Vigo
Osasuna, on home soil, should be the favourites, but Arrasate's side are currently missing a number of important players. Celta, on the other hand, picked up an impressive point against Atletico last time out, and we are finding it difficult to predict the visitors to lose this game.
Real Valladolid vs. Barcelona (Saturday, 6.30pm)
The Spanish champions will enter this weekend's clash off the back of a 1-0 win over Espanyol on Wednesday, while Valladolid suffered a 2-1 defeat at Valencia 24 hours earlier.
We say: Valladolid 0-2 Barcelona
Only a win will do for Barca as they chase down Real Madrid, and we are finding it difficult to see the champions slipping up here. De Jong's expected return is excellent news for the Catalan giants, who should have too much for the home side on Saturday night.
Atletico vs. Real Betis (Saturday, 9.00pm)
Diego Simeone's side were held to a 1-1 draw at Celta Vigo on Tuesday, while Betis will enter the match off the back of an impressive 3-0 success at home to Osasuna.
We say: Atletico 1-0 Betis
Betis put in a strong performance against Osasuna in their last match, but there are not many more tougher grounds to visit than the Wanda Metropolitano. Atletico will be keen to return to winning ways after sharing the points with Celta, and we are expecting a narrow home victory on Saturday night.