Sevilla vs. West Ham (Thursday, 5.45pm)
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West Ham United return to Europa League action on Thursday evening for the first leg of their last-16 tie with Sevilla.
While the Hammers make the trip to Estadio Ramon Sánchez Pizjuan sitting in sixth position in the Premier League standings, the Spanish giants are second in La Liga.
We say: Sevilla 2-1 West Ham United
Despite the contrasting European experience of the two teams, this makes for an intriguing clash. West Ham will fancy their chances of collecting at least a draw ahead of the second leg in London, but we are backing Sevilla's extra cohesion and quality to prove decisive in claiming a narrow win.
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Barcelona vs. Galatasaray (Thursday, 8.00pm)
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Barcelona will aim to move one step closer to Europa League glory when they welcome Galatasaray to Camp Nou for the first leg of their last-16 battle on Thursday evening.
The Catalan giants defeated Napoli 5-3 on aggregate to make it this far, while their visitors qualified first from the group stage in Europe's secondary competition.
We say: Barcelona 3-0 Galatasaray
Barcelona certainly appear to be finding their feet under Xavi and have had no problems on the goalscoring front recently - largely thanks to an extensive amount of options in the final third.
While Galatasaray have certainly improved under their new man at the helm, keeping the back door shut has not been their forte, and an in-form Blaugrana should claim a healthy first-leg advantage.
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> How Barcelona could line up against Galatasaray
> Barcelona injury, suspension list vs. Galatasaray
Rangers vs. Red Star (Thursday, 8.00pm)
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Rangers will continue their continental adventure when they play host to Red Star Belgrade for the first leg of their Europa League last-16 tie on Thursday night.
The Scottish giants secured a memorable playoff victory against Borussia Dortmund in the previous round, while their Serbian counterparts finished top of their group.
We say: Rangers 2-1 Red Star Belgrade
Rangers' impressive victory over Dortmund will provide them with plenty of confidence for their two-legged tie with Red Star, and although the visitors may frustrate the hosts at times on Thursday night, Van Bronckhorst's men should do enough in front of the Ibrox faithful to secure a slender win and take an advantage into next week's second leg.
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Braga vs. Monaco (Thursday, 8.00pm)
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Portuguese outfit Braga will welcome French side Monaco to the Estadio Municipal de Braga for the first leg of their Europa League last-16 tie on Thursday night.
The hosts head into this contest off the back of two draws in the Primeira Liga, while the visitors claimed a slender 1-0 Ligue 1 victory away at Marseille last weekend, ending a run of four games without a win.
We say: Braga 1-1 Monaco
A closely-fought contest between two evenly-matched sides is set to take place on Thursday, with Braga arguably the slight favourites given their impressive home record – losing only one of their 17 home matches across all competitions this season.
Having said that, we expect the visitors to claim at least a draw, with the tie to be nicely poised for next weeks' second leg in France.
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Atalanta vs. B. Leverkusen (Thursday, 8.00pm)
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With a place in the Europa League quarter-finals up for grabs, Atalanta BC and Bayer Leverkusen get their last 16 tie underway on Thursday night.
The teams meet in Bergamo, with the hosts starting to falter in domestic competition and their visitors in high spirits following a draw at Bayern Munich last weekend.
We say: Atalanta BC 1-1 Bayer Leverkusen
The combination of declining form and a modest home record means that Atalanta are not the same well-oiled machine that impressed Europe with their attractive style and odds-defying achievements.
Therefore, a more fluent and confident Leverkusen will head into the second leg on level terms, with their incisive forward line capable of frightening even the tightest of defences.