The 20-year-old bagged his first Premier League goal against West Bromwich Albion before having to be taken off with a hamstring complaint, and Mikel Arteta has admitted that he does not know how serious the issue is.
Nicolas Pepe and Willian both scored stunning long-range efforts in Sunday's 3-1 triumph, but the latter's place is at risk as Pierre-Emerick Aubameyang is expected to return to the starting lineup on Wednesday.
Xhaka is joined by David Luiz (hamstring) and Pablo Mari (ankle) on the recent injury list - although Arteta has only ruled Luiz out of this game - meaning that Rob Holding and Gabriel Magalhaes are set to pair up in defence once again.
Bukayo Saka seems in need of a rest so may be granted it here as Kieran Tierney returns at left-back, while Calum Chambers will hope to beat Hector Bellerin and Cedric Soares to the right-back spot once more.
Arsenal possible starting lineup: Leno; Chambers, Holding, Gabriel, Tierney; Partey, Elneny; Pepe, Odegaard, Aubameyang; Lacazette
Watch the Sports Mole Football Shorts prediction for this game below: