The right-back appeared to tweak a muscle when stretching to make a clearance in last week's win against Chelsea, and while his issue was not initially thought to be serious, he will not be available in midweek.
Thomas Partey and Mohamed Elneny should both keep Dani Ceballos out of the team following strong showings at Stamford Bridge, with Real Madrid loanee Martin Odegaard likely to continue in the number 10 role.
Another start for Pierre-Emerick Aubameyang would restrict Alexandre Lacazette to a substitute outing, while Emile Smith Rowe will aim to become the first player aged under 21 to score in three consecutive Premier League games for Arsenal since Cesc Fabregas in September 2007.
Arsenal possible starting lineup: Leno; Chambers, Holding, Mari, Tierney; Partey, Elneny; Saka, Odegaard, Smith Rowe; Aubameyang
Watch the Sports Mole Football Shorts prediction for this game below: