Both players missed the weekend's win over Aston Villa due to personal reasons, and it remains to be seen if they will come back for the penultimate gameweek of the season.
Nathaniel Clyne's participation is also up in the air due to a bout of sickness, while Roy Hodgson will definitely have to cope without James McArthur, Mamadou Sakho, Connor Wickham and Nathan Ferguson.
Vicente Guaita and Wayne Hennessey both took their places on the bench as Jack Butland was handed his first Premier League appearance in a Palace shirt, but Hodgson has hinted at a recall for Guaita this week.
Tyrick Mitchell was never at risk of losing his place to Van Aanholt following his chested winner against Villa, but one alteration in defence could see Scott Dann recalled as Hodgson carefully manages Gary Cahill's fitness.
James McCarthy may not be ready for two games in quick succession just yet either, so Jairo Riedewald could earn a recall to the middle of the park alongside Jeffrey Schlupp, while Jordan Ayew will hope to return to the right over Andros Townsend.
Crystal Palace possible starting lineup: Guaita; Ward, Kouyate, Dann, Mitchell; Ayew, Riedewald, Schlupp, Eze; Zaha, Benteke
Watch the Sports Mole Football Shorts prediction for this game below: