Alexandre Lacazette's strong run of form came to an end as he suffered a thigh injury against Fulham, but the striker is in contention for this game, while Pierre-Emerick Aubameyang is also back but may only be considered for a spot on the bench after recovering from malaria.
Eddie Nketiah and Gabriel Martinelli may battle it out to lead the line, although Folarin Balogun - who recently penned a new deal with the club - is another option, but Lacazette will hope to be given the nod if he proves his fitness.
Bukayo Saka is a shoo-in on the right, but Martin Odegaard's return to fitness could spell trouble for Emile Smith Rowe, especially seeing as Nicolas Pepe should not be dropped having registered five goals and four assists in this season's tournament so far.
Dani Ceballos and Thomas Partey ought to continue in the engine room as Granit Xhaka continues at left-back, although the Switzerland international did not cover himself in glory for Everton's winner on Friday and Kieran Tierney may be ready in time.
Calum Chambers appears to have established himself as the Gunners' first-choice right-back over Hector Bellerin and Cedric Soares, while Gabriel Magalhaes will hope to demote Pablo Mari back down to the bench.
Arsenal possible starting lineup:
Leno; Chambers, Holding, Gabriel, Xhaka; Partey, Ceballos; Saka, Odegaard, Pepe; Lacazette