The Yellow Submarine remain without midfielder Vicente Iborra as he recuperates from a knee problem, but they are otherwise in good shape before Emery renews hostilities with Arsenal.
Samuel Chukwueze opened the scoring in their 2-1 defeat to Barcelona and will provide an attacking threat down the right, while Manu Trigueros should feature on the opposite side despite seeing red at the weekend.
Up top, Gerard Moreno will feel confident of adding to his tally of 26 goals across all competitions this season, and he has registered a goal or assist in his last six Europa League games.
Villarreal possible starting lineup:
Asenjo; Foyth, Albiol, Torres, Estupinan; Chukwueze, Parejo, Capoue, Trigueros; Moreno, Alcacer