Leyton Orient have moved to the top of League Two thanks to a 3-0 win over Teddy Sheringham's Stevenage in League Two tonight.
Scott Fenwick scored the winner for Hartlepool United, who also made it three wins from three, at home to Newport County, in a result which keeps the South Wales club near the bottom with just one point so far.
The West Country side took the lead just before the break through Jake Jervis, before the floodgates opened in the second half as Reuben Reid, Graham Carey and a second goal from Jervis put them out of sight, and made sure that Carlisle remain winless.
Oxford United also won their first game of the season as Callum O'Dowda, Kemar Roofe and Danny Hylton scored in a 3-1 win over Notts County. Thierry Audel had given County the lead in the 21st minute.
Stuart Sinclair scored a dramatic 94th-minute winner as Bristol Rovers earned the three points away at Luton Town, while James Berrett scored the only goal at Bootham Crescent as York City beat Yeovil Town.
Results in full (half-time scores in brackets): Accrington Stanley 1-0 Mansfield Town (1-0), AFC Wimbledon 1-2 Cambridge United (1-0), Barnet 2-0 Northampton Town (0-0), Crawley Town k-k Portsmouth (0-0), Dagenham & Redbridge 1-2 Exeter City (0-1), Hartlepool United 1-0 Newport County (0-0), Leyton Orient 3-0 Stevenage (0-0), Luton Town 0-1 Bristol Rovers (0-0), Morecambe 0-1 Wycombe Wanderers (0-0), Oxford United 3-1 Notts County (1-1), Plymouth Argyle 4-1 Carlisle United (1-0), York City 1-0 Yeovil Town (0-0)