Accrington vs. Bolton (Saturday, 3.00pm)
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Bolton Wanderers have the opportunity to leapfrog Accrington Stanley in League One on Saturday, when they make the short trip to the Wham Stadium.
Both sides enter this weekend's fixture after recording defeats in midweek, with their form very similar having won two, drawn one and lost three in their last six games across all competitions.
We say: Accrington Stanley 1-1 Bolton Wanderers
These two teams have been in very similar form and both enter this fixture on the back of defeats, suggesting that it is going to be a cagey affair as neither team will want to record consecutive losses.
Bolton will be aware of their poor form away from home recently, and a point on the road this Saturday could be viewed as a good point to break the losing cycle on their travels.
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Charlton vs. Cambridge (Saturday, 3.00pm)
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Charlton Athletic will welcome Cambridge United to The Valley on Saturday with both sides looking to claim their fourth consecutive victory in all competitions.
The two teams have an identical points tally, but the hosts sit a place higher in 14th position courtesy of a better goal difference than their opponents.
We say: Charlton Athletic 2-1 Cambridge United
Although Camrbidge will be full of confidence after their comfortable victory in midweek, we think they will struggle against a Charlton side that are in excellent form and our belief is that the hosts will claim their fourth consecutive victory in all competitions.
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Cheltenham vs. Lincoln (Saturday, 3.00pm)
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Cheltenham Town welcome Lincoln City to the Jonny-Rocks Stadium on Saturday, with both teams looking to bounce back from particularly disappointing defeats last time out.
The hosts were hammered 5-0 at home to Cambridge United to leave them 12th in the League One table, while Lincoln slumped to a 2-0 loss at relegation-threatened Crewe Alexandra.
We say: Cheltenham Town 2-0 Lincoln City
Lincoln cannot buy a goal at the moment, and the fact that they only had two shots on target against one of the worst defences in the league last time out suggests that their troubles may not be over yet.
Cheltenham will also be coming into this match short of confidence - and their recent defensive record should give Lincoln some belief that they might end their drought - but the hosts should still have enough to claim all three points this weekend.
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Crewe vs. Sheff Weds (Saturday, 3.00pm)
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Crewe Alexandra have an opportunity to extend their unbeaten run at Gresty Road to five matches in all competitions when they welcome Sheffield Wednesday to northwest England on Saturday.
The Railwaymen are second from the bottom in League One despite a 2-0 win over Lincoln City earlier this week, while the Owls are unbeaten in 11 straight league fixtures, following a 0-0 draw against Portsmouth.
We say: Crewe Alexandra 1-2 Sheffield Wednesday
Momentum is with the Railwaymen heading into this fixture, and even though they are not as bad as their current record would indicate, they have only beaten one team, currently in the top 10 in League One.
The Owls have quality and consistency in abundance, and their rental players have made a significant impact for them this season, and we expect those individuals to propel them to another road win this weekend.
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Doncaster vs. Shrewsbury (Saturday, 3.00pm)
Doncaster Rovers will be keen to pick up points in a bid to improve on their desperate position at the bottom of League One when they welcome Shrewsbury Town to the Keepmoat Stadium on Saturday afternoon.
Shrewsbury themselves are currently hovering just above the drop zone, making this weekend's clash an important fixture in the race to avoid the League One drop.
We say: Doncaster Rovers 1-2 Shrewsbury Town
Neither side can afford anymore League One slip-ups, but whilst the writing looks to be on the wall for Doncaster, hope remains in the Shrewsbury camp that they can still find a way out.
Shrewsbury boast the upper-hand over Doncaster in recent years and they will likely take another three points this weekend.
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Fleetwood vs. Gillingham (Saturday, 3.00pm)
In what is shaping up to be a crucial battle at the bottom of League One, Fleetwood Town will welcome fellow-strugglers Gillingham to Highbury Stadium on Saturday afternoon.
Both teams currently occupy places in the relegation zone, with Fleetwood entering the weekend one point and one place above their opponents.
We say: Fleetwood Town 2-0 Gillingham
Both sides will be targeting this clash as a decisive meeting in their bid for survival, but one team heads into the fixture in significantly better form than the other.
Expect more misery to be piled on Gillingham here, with Fleetwood taking another impressive victory in the comfort of their own home.
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MK Dons vs. Oxford Utd (Saturday, 3.00pm)
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Both MK Dons and Oxford United will continue their push towards the League One playoff spots when the pair meet at Stadium MK on Saturday afternoon.
The visitors currently sit fifth, boasting a two-point and two-place gap between themselves and their hosts.
We say: MK Dons 1-2 Oxford United
It is unlikely that either of these two sides will break into the automatic promotion spaces, making the playoffs their only viable route out of the division.
MK Dons may be the home side, but Oxford have the experience in recent years, making an away win the most likely outcome.
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Portsmouth vs. Morecambe (Saturday, 3.00pm)
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Portsmouth will look to continue their revival under Danny Cowley when they welcome Morecambe to Fratton Park on Saturday afternoon.
It will be the pair's first meeting in the third tier, having met for four consecutive seasons as League Two clubs.
We say: Portsmouth 2-1 Morecambe
Portsmouth should be looking at this clash against one of the division's lesser sides with optimism as they look to continue their revival.
Morecambe have been a thorn in Pompey's side during seasons gone by, so it could be closer than some expect.
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Rotherham vs. Burton Albion (Saturday, 3.00pm)
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League One league leaders Rotherham United will look to extend their unbeaten run to 20 games in all competitions when they face Burton Albion on Saturday.
Meanwhile, the visitors sit in 10th place, and they will be hoping to return to winning ways after losing their last two matches.
We say: Rotherham United 2-0 Burton Albion
Given their superb form this season, it is hard to see this encounter ending in anything but a home win, and we expect the Millers to clinch their fourth successive home league victory on Saturday.
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Sunderland vs. Plymouth (Saturday, 3.00pm)
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Steven Schumacher will be take charge of his first away game as Plymouth Argyle boss when he takes his side to the North East for Saturday's League One encounter with Sunderland.
The hosts are looking to continue a five-game unbeaten league run, which has seen them climb up to fourth place as they head into the weekend only two points adrift of the automatic promotion places.
We say: Sunderland 1-1 Plymouth Argyle
With only two points separating the sides in the table, this is likely to be a closely-fought contest, and although Sunderland are formidable at home, we think that Plymouth may snatch a point from the encounter.
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Wigan vs. Ipswich (Saturday, 3.00pm)
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Ipswich Town will travel to Wigan Athletic on Saturday, and the visitors will be looking to end a three-game winless run in all competitions.
Meanwhile, Wigan head into the weekend in second position, and they will be aiming to extend their unbeaten run to 11 matches.
We say: Wigan Athletic 2-1 Ipswich Town
Ipswich know that if they harbour ambitions of reaching the playoffs then an upturn in results is required, but we that think they will fall short on Saturday when they travel to a Wigan side who have proven to be a strong force in League One this term.
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Wycombe vs. AFC Wimbledon (Saturday, 3.00pm)
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Wycombe Wanderers sit in third place in League One, and they will aim to move into the top two when they face AFC Wimbledon on Saturday.
Both sides will look to extend their unbeaten runs to five games in all competitions after enjoying a recent run of positive results.
We say: Wycombe Wanderers 2-1 AFC Wimbledon
Wycombe are a formidable force on home turf, and though Wimbledon enter the contest in impressive form, we think that the hosts will claim a narrow victory.