Klopp may be forced into a reshuffle for Sunday afternoon's clash at Anfield, as all three defensive options to partner Dejan Lovren in the heart of the back four could miss out.
"[We have] a few little things from the last game, it doesn't make it much easier," he told reporters. "Little bit muscle problems, Joel Matip, Lucas Leiva [and] still a problem with Ragnar Klavan.
"[Klavan] was a very, very small medial ligament, but could be also really not enough time until Crystal Palace."
Klopp may turn to Joe Gomez should all three players miss out, with the 19-year-old in line to make his first Premier League start since September 2015.