B. Leverkusen vs. Rangers (Thursday, 5.55pm)
Whoever prevails from this match will take on either Inter Milan or Getafe in the quarter-finals later this month.
We say: Bayer Leverkusen 2-1 Rangers
While Rangers will have benefitted from 90 minutes of competitive football at the weekend, Leverkusen can afford to play this game at their own pace. With that in mind, we feel that the home side will run out comfortable victors on Thursday evening.
Sevilla vs. Roma (Thursday, 5.55pm)
The tie will be contested over just one leg and pits together sides that finished fourth and fifth in their domestic leagues this season.
We say: Sevilla 1-0 Roma
Sevilla have had an extra two weeks' rest compared to Roma heading into this match, but it remains to be seen just how much of an advantage - or indeed disadvantage - that will be. Both sides ended their domestic campaigns in impressive form, but we can see Sevilla edging this first ever competitive meeting between the clubs.
Wolves vs. Olympiacos (Thursday, 8.00pm)
Wolverhampton Wanderers and Olympiacos meet at Molineux on Thursday evening with their Europa League last-16 tie locked at 1-1 on aggregate.
Whoever progresses from the fixture later this week will take on either Roma or Sevilla in the quarter-finals.
We say: Wolverhampton Wanderers 2-1 Olympiacos
Having failed to qualify for next season's competition, there will be a few nerves within the Wolves side during this game. Nevertheless, they are due a response after their poor performance last time out, and we feel that they should just do enough to edge out Olympiacos on this occasion.
Basel vs. Frankfurt (Thursday, 8.00pm)
Basel stormed to a 3-0 victory in the first leg and - barring any disasters - can look forward to reaching the last eight of the competition for the first time since the 2013-14 campaign.
We say: Basel 1-1 Frankfurt
Frankfurt were simply outclassed in the first leg and must now navigate the difficult task of putting four past a Basel side that have kept clean sheets in their last four Europa League outings. We are expecting a more closely-fought game in the second leg, but Basel should do enough to book their spot in the quarter finals.