Maloney hasn't trained all week after suffering with an illness and his place has been taken by Roger Espinoza, in one of three changes from the side that lost at home to Norwich City last week.
Watford: Gomes, Cathcart, Bassong, Angella, Paredes, Munari, Tozser, Abdi, Anya, Deeney (c), Vydra
Subs: Gilmartin, Guedioura, Forestieri, Doyley, Pudil, Dyer, Ighalo.
Wigan Athletic: Carson, Taylor, McCann, Watson, McClean, McManaman, Boyce (C), Espinoza, Cowie, Perch, Barnett
Subs: Al-Habsi, Tavernier, Maloney, Forshaw, Figueroa, Fortune, Delort.