Charlton vs. Wigan (Saturday, 12.30pm)
Wigan Athletic travel to The Valley to face Charlton Athletic knowing that victory could be enough to secure their Championship future, despite the prospect of suffering a 12-point deduction due to being placed into administration.
Meanwhile, the Addicks head into Saturday's encounter sitting a point above the relegation zone with a superior goal difference to their rivals.
We say: Charlton Athletic 1-2 Wigan Athletic
Charlton have shown in the past that they are capable of keeping things tight at the back. However, on the back of such a commanding win in midweek, we cannot predict anything other than a Wigan win, potentially via a late goal.
Stoke vs. Brentford (Saturday, 12.30pm)
Meanwhile, the Potters play host to the promotion contenders realistically requiring just one point to guarantee their second-tier status for another 10 months.
We say: Stoke City 1-2 Brentford
While we feel that this contest could be more competitive than many expect, Brentford will be confident of eventually wearing down their hosts, potentially during the latter stages when Stoke are content to avoid defeat.
Preston vs. Birmingham (Saturday, 3.00pm)
The Lilywhites have fallen five points adrift of the playoffs with two games to go following a poor run of form, while Birmingham have also struggled for wins and are down in 19th.
We say: Preston 2-0 Birmingham
Preston may have struggled for wins either side of the three-month hiatus, but Birmingham's form has been even worse. The Blues have failed to win any of their last 15 matches in all competitions and have lost four of their last five, a run that we can see being extended this weekend.
Swansea vs. Bristol City (Saturday, 3.00pm)
Swansea currently occupy eighth spot - three adrift of the top six - whereas Bristol City lie 10th before the penultimate round of fixtures.
We say: Swansea City 2-3 Bristol City
The two clubs will certainly not want to give up hope of a top-six finish just yet, but the odds are stacked against both sides heading into the penultimate round of fixtures. That being said, Swansea are short at the back due to injuries and Bristol City are brimming with confidence right now, so we are backing a slender away win in what promises to be a fascinating affair this weekend.
Middlesbrough vs. Cardiff (Saturday, 3.00pm)
Both teams picked up big victories in midweek to keep their respective fates in their own hands, but the pressure is still on as Neil Warnock prepares to face his former club.
We say: Middlesbrough 0-1 Cardiff City
Middlesbrough are without a home win since Boxing Day, losing half of their 10 matches at the Riverside Stadium since then. A defeat to Fulham last week aside, Cardiff have been in great form on their travels and we expect them to make it four wins in a row against Boro - all the by the same scoreline - in this weekend's clash.
QPR vs. Millwall (Saturday, 3.00pm)
Millwall currently sit two points adrift of the top six as things stand, whereas QPR lie in 16th and have little to play for at this very late stage.
We say: QPR 1-2 Millwall
Millwall know what is at stake here - anything other than a win and their promotion hopes may be dead and buried before the final day of the season. QPR have struggled for form recently, though, so we are backing Millwall to keep their playoff dream alive with a narrow victory on Saturday.
Blackburn vs. Reading (Saturday, 3.00pm)
However, having both suffered defeats in midweek, there will be an eagerness to return to winning ways at Ewood Park.
We say: Blackburn Rovers 1-1 Reading
All things considered, this is a difficult match to call. However, we are favouring the visitors, who have shown more consistency than their hosts in recent weeks.
Fulham vs. Sheff Weds (Saturday, 3.00pm)
Fulham will be looking to get back to winning ways in the Championship when they welcome Sheffield Wednesday to Craven Cottage in their penultimate regular season fixture.
The Cottagers were held by West Bromwich Albion last time out to all but end their automatic promotion hopes, while Wednesday played out a stalemate with Huddersfield Town to remain 15th.
We say: Fulham 2-0 Sheffield Wednesday
Fulham's automatic promotion hopes may well be over by the time they kick off against Wednesday, but Parker will want to keep his side's positive form going regardless. The Whites have won four of their last five home matches without conceding and we are backing them to come out on top this weekend.
Hull City vs. Luton (Saturday, 3.00pm)
The Tigers suffered an 8-0 loss to Wigan Athletic on Tuesday to leave them level on points with Luton, who earned a draw against Queens Park Rangers on the same day.
We say: Hull City 0-1 Luton Town
Quite how Hull will react to their eight-goal thrashing at the hands of Wigan - a fourth defeat on the spin - remains to be seen. Luton have made themselves tough to beat of late and now need to turn draws into wins, with this trip to the KCOM Stadium presenting them with a huge opportunity to do exactly that.