Despite losing out 3-1 to Arsenal in their last match, the Hammers have picked up three wins and a draw from their opening seven games of the campaign.
It hasn't been quite the same return to the Premier League for the Saints, who currently sit 17th in the table.
West Ham will be without Ricardo Vaz Te, who was recently ruled out for three months with a shoulder injury, while Andy Carroll is expected to start in attack following his return from a hamstring problem.
West Ham: LWDDWL
West Ham: Jaaskelainen; Reid, McCartney, Collins, Tomkins; Jarvis, Nolan, Noble, Benayoun; Carroll, Cole
Southampton: Gazzaniga; Yoshida, Fonte, Fox, Richardson; Schneiderlin, S Davis, Lallana, Puncheon; Lambert, Rodriguez
Sports Mole says: 2-1