The Seville outfit have picked up six points from their first four matches of the season to sit fifth in the table, while Valencia have collected seven points from their opening four encounters to occupy second spot.
Valencia have made an encouraging start to the season considering that their summer transfer business has seen them sell a number of key players and fail to make a first-team signing at this stage.
It is going to be difficult for Los Che to push for a European finish this season, but they have made a solid start to the campaign, picking up seven points from their four matches to sit second in the table.
Valencia actually finished ninth in Spain's top flight last season, meaning that they can fully focus on La Liga in 2020-21 due to the lack of European football at the Mestalla.
Betis, meanwhile, made an impressive start to their campaign, picking up maximum points from their first two matches against Alaves and Real Valladolid to sit top of the table.
Manuel Pellegrini's side have lost their last two, though, suffering a 3-2 defeat at home to Real Madrid on September 26 before being on the wrong end of a 3-0 scoreline at Getafe on Tuesday night.
Betis actually finished 15th in La Liga last season, but it is worth remembering that they claimed sixth in 2017-18 and certainly have the quality to push higher up the table this term.
The omens are not exactly fantastic for the Seville club, though, as they have only won one of their last seven La Liga encounters with Valencia and lost 2-1 in the corresponding match last season.
Valencia La Liga form: WLDW
Real Betis La Liga form: WWLL
As for Betis, Emerson is available after serving a one-game suspension against Getafe, but Francis Guerrero, Dani Martin and Victor Camarasa remain on the sidelines through injury, while Aissa Mandi will serve a ban due to the red card that he picked up in the Spanish capital.
Valencia possible starting lineup:
Domenech; Correia, Diakhaby, Guillamon, Gaya; Musah, Wass, Kondogbia, Blanco; Gomez, Gameiro
Real Betis possible starting lineup:
Bravo; Emerson, Bartra, Sidnei, Moreno; Rodriguez, Carvalho; Juanmi, Fekir, Canales; Iglesias
We say: Valencia 2-2 Real Betis
There has only been one draw in the last six meetings between these two sides but that came at the Mestalla in September 2018. Valencia will be full of confidence following an excellent win at Sociedad, but Betis have a number of excellent players, and we are backing a high-scoring draw on Saturday night.