Los Che, who are currently 14th in the table, will enter this weekend's match off the back of a 1-0 win over Elche last weekend, while Athletic booked their spot in the semi-finals of the Copa del Rey on Thursday night courtesy of a penalty-shootout victory over fellow top-flight club Real Betis.
Athletic will play the final of the 2020 Copa del Rey against Real Sociedad at the start of April, but they are also on course to make the final of the 2021 competition, having booked their spot in the semi-finals with a win over Betis on Thursday night.
Raul Garcia scored a 94th-minute leveller for Marcelino's side in Seville, and the visitors went on to triumph on penalties, joining Sevilla, Levante and Barcelona in the final four of the tournament.
Athletic's league form has been slightly disappointing, though, winning just two of their last six and losing three of their last five, including a 2-1 defeat away to Barca last weekend.
A total of 24 points from 20 matches has left the Basque side in 11th position in the table, just five points clear of the relegation zone, and they will certainly be wary of dropping down the division.
The eight-time Spanish champions picked up a point in the reverse match at Mestalla earlier this season but suffered a 1-0 defeat when Valencia visited San Mames for the corresponding fixture last term.
There is no getting away from the fact that it has been a disappointing season for Valencia, who have only picked up 23 points from their 21 matches to sit down in 14th position in Spain's top flight.
Champions in 2003-04, Los Che finished ninth last season, and they would certainly take that position this term, having struggled to show any form of consistency in 2020-21.
Javi Gracia's side have no Copa del Rey or European football between now and the end of the campaign, though, meaning that they can put their full focus on avoiding being pulled into the bottom three.
Valencia lost their last away game at Atletico Madrid on January 24 but will enter this weekend's contest off the back of a positive result, beating Elche 1-0 courtesy of a first-half effort from Daniel Wass, while they have only been beaten in one of their last five matches in Spain's top flight.
Athletic Bilbao La Liga form: DLWLWL
Athletic Bilbao form (all competitions): WWWWLW
Valencia La Liga form: LDWDLW
Valencia form (all competitions): WWDLLW
Inaki Williams started on the bench against Betis in the Copa del Rey but should be back in the side for this match, while Asier Villalibre is likely to retain his position in the final third of the field.
Athletic Bilbao possible starting lineup:
Simon; Capa, Yeray, Martinez, Berchiche; De Marcos, Vencedor, D Garcia, Berenguer; Villalibre, Williams
Valencia possible starting lineup:
Domenech; Correia, Gabriel, Guillamon, Gaya; Wass, Racic, Soler, Guedes; Gomez, Vallejo
We say: Athletic Bilbao 1-1 Valencia
Valencia have proven difficult to beat in the league since the start of 2021, while Athletic will enter the match off the back of an energy-zapping clash with Betis on Thursday. A draw would not be the worst result in the world for either side, and we are tipping a 1-1 in this contest.