Having sprung something of a surprise to reach the quarter-finals of last season's Champions League, Monaco are now facing up to the prospect of a campaign without featuring in Europe's top club competition.
Although a comeback appears to be a tough ask, they can at least take some solace from their recent home record in European fixtures.
Of the last 11 visitors to the Stade Louis II, only Arsenal last term have left with a victory. During that time the Ligue 1 outfit have recorded six victories and drawn the other four encounters.
However, Leonardo Jardim could well be concerned by his side's domestic form heading into this fixture. While they are unbeaten in their opening three fixtures, recent draws against Lille and Toulouse came as a result of uninspiring performances.
What will also be a cause of concern for Jardim is the fact that Monaco have struggled to convert their chances. They actually had 13 shots in the Mestalla last week, which was three more than their Spanish counterparts.
Recent form: LLDWWL
Recent form (all competitions): WWWDLD
Sofiane Feghouli's goal four minutes from the end of the first leg could well prove itself to be a crucial moment when this tie is concluded.
Had Nuno Espirito Santo's men taken just a 2-1 lead with them to Southern France, it would be a much different prospect than the one that awaits them now.
As far as their European record is concerned, Los Che may have lost their last two away matches without scoring a goal, yet they can at least look back on a positive record in France. In 10 outings, they have been beaten just once, with four victories to boast.
There are those that believe only complacency will stop Valencia advancing, but Santo, who won the competition under Jose Mourinho's management at Porto in 2004, has warned his players not to get carried away by the result that they picked up in the opening leg.
"The result is there now - our objective was to win this tie. Now we will be going to Monaco to compete and we know what awaits us. Nothing is definitive in this competition and we will be going there with the same ambition to win. There are no favourites," he recently told reporters.
Valencia warmed up for this clash with a relatively mundane 0-0 draw away at Rayo Vallecano on the opening day of the new La Liga campaign on Saturday.
Recent form: WDWLDW
Recent form (all competitions): LDLLWD
He started among the substitutes in Valencia, but with Monaco in need of goals, summer signing from AC Milan El Shaarawy could well be included up front by Jardim.
Aside from that, it is unlikely that the Les Rouges et Blancs head coach will make any other alterations to his starting lineup.
As for Valencia, Mathew Ryan should keep his place in goal with Diego Alves ruled out, while with Nicolas Otamendi having recently switched to Manchester City, Ruben Vezo is expected to partner Shkodran Mustafi in defence.
Monaco possible starting lineup:
Subasic; Ragic, Carvalho, Wallace, Elderson; Fabinho, Toulalan, Pasalic; Silva, Martial, El Shaarawy
Valencia possible starting lineup:
Ryan; Barragan, Mustafi, Vezo, Gaya; Perez, Feghouli; Parejo, De Paul, Rodrigo; Alcacer
Head To Head
Prior to last week's encounter, the only other competitive meetings between these two clubs came during the first round of the European Cup Winners' Cup in 1990.
The Spaniards won through 5-3 on aggregate, with a 3-3 draw having been played out at the Stade Louis II.
Nevertheless, Monaco have recorded some big home victories over Spanish opposition, including an 8-3 triumph over Deportivo La Coruna in 2003.
We say: Monaco 1-1 Valencia
With a number of quality players in the squad, Valencia should be able to manage their way through this game and subsequently into the group stages of the Champions League. As Monaco push forward in search of goals, there is bound to be space to exploit.