The Three Lions head to Sao Paulo having lost their opening game of the tournament 2-1 against Italy, and their upcoming meeting with the South Americans is seen as a must-win game for Roy Hodgson's side.
However, Uruguay are also in need of a victory following their surprise opening defeat to Costa Rica.
Plenty of debate has circled around whether Wayne Rooney will be dropped for the game, but the forward is likely to keep his place in the starting XI this time around.
However, Hodgson could still make a few changes to his lineup, with a place in the team for Jack Wilshere being widely mooted.
Possible starting lineups
Uruguay: Muslera; Caceres, Lugano, Godin, Pereira; Gargano, Arevalo; Rodriguez, Forlan, Suarez; Cavani
England: Hart; Johnson, Jagielka, Cahill, Baines; Gerrard, Wilshere; Welbeck, Rooney, Sterling; Sturridge
Sports Mole says: 0-2