Poyet has stressed that he is not one for knee-jerk reactions, but has admitted that Mannone's recent form is a concern.
He told reporters: "Normally I don't change the keeper when they have a bad game.
"Sometimes, you need to accept mistakes in the overall performance, be it from a keeper, a manager or a No. 9. But if it's two bad games, then he starts to have a problem."
Mannone, 26, has been preferred to summer signing Costel Pantilimon after being named Sunderland's Player of the Year last season, but now the former Manchester City stopper could be given his chance.