Spurs are understood to have agreed a £25m deal with the Brazilian, who has not made a single start for PSG across all competitions this season.
Sky Sports News reports that Moura has now landed in London to discuss personal terms and undergo a medical with Spurs, who hope to complete the transfer before the end of the day.
The 25-year-old has previously been linked with the likes of Manchester United, but has fallen out of favour in the French capital this season following the arrival of Neymar in the summer.
PSG were keen to complete a permanent deal to offload Moura due to Financial Fair Play rules, although the switch is unlikely to be finalised in time for the winger to feature in Wednesday night's clash with Manchester United.
Moura has scored a total of 46 goals in 229 appearances for PSG in all competitions, helping the club to four league titles and three Coupe de France crowns during his time in Paris.