The 24-year-old, who last played for Spurs in August, is expected to have his operation on Monday but the former Portsmouth boss is unaware of how long the player will be sidelined for.
"He needs another operation,” said Redknapp. “He's already had one but there is still a problem with him. It's a blow. He will be out for a while."
Huddlestone has clocked up 122 appearances for the London club since he joined White Hart Lane from Derby County in 2005.