The England international striker achieved the feat last night by scoring twice in his side's 4-0 League Cup victory over Aston Villa, taking his tally for the Lilywhites to 139.
"If someone would have said to me when I first walked into Spurs that I would be in the top five all-time goal scorers in the club's history, I would have probably said 'are you being serious?'" he told the club's official website. "I look at all the great players in the top 10 and to be fifth, it's a dream.
"I'm trying not to think about it too much as it's a long season, but of course it's at the back of my mind every time I go on the pitch because I want to score. It's something special and I want to keep it going."
Defoe spent four years at White Hart Lane up until 2008 before a spell with Portsmouth. He then returned to Tottenham in 2009.