The Dutchman has already admitted that Spurs have contacted him in the past, and has also spoken of his interest in managing a club in the Premier League.
Van Gaal has now confirmed that he will leave his current post after the 2014 World Cup finals in Brazil.
"I have said before that a challenge should be a club in the Premier League. That's a challenge. Maybe Tottenham are coming, but first we have to go to Brazil," Van Gaal is quoted as saying by The Mirror.
"I will definitely not be in charge for the European [Championship qualifying] campaign. I don't know where I will go next, normally I go with my pension, go to live in Portugal, but maybe there will come a new challenge."
Van Gaal has also managed the likes of Barcelona and Ajax in his career.