Spurs travel to the KC Stadium on Saturday to face Hull City, and Lloris believes that it is important for the team to find their focus again as they bid for a place in the Champions League.
"We have to be positive," the French goalkeeper told the club's official website. "OK, when you lose at home like that, it's never easy, but that's football.
"We are in fifth place, three points behind Liverpool and anything could happen between now and the end of the season. We need to focus again and have a good reaction against Hull."
The loss to City was Tottenham's first since Tim Sherwood was appointed head coach.