When asked if his players were feeling the effects of their recent Europa League exploits, Villas-Boas told Sky Sports News: "No. We played lots of players who were not involved recently and had a couple of fresh legs on the pitch - five at least.
"We had a decent game, but we couldn't create as much as we normally create at home offensively.
"It was one of those defeats we have to reflect on. The desire and effort was there, but things just didn't go our way in terms of football."
The defeat means that Tottenham have slipped down to fourth place in the Premier League table.