Spurs have lost their last two in the league to Liverpool and Leicester City, though, and currently sit sixth in the table, six points off the summit.
Here, Sports Mole looks at how Tottenham could line up at Molineux.
Tottenham will again be without the services of Japhet Tanganga due to a shoulder problem, while Giovani Lo Celso has been ruled out of the festive period with the thigh issue that he picked up against Leicester.
Gareth Bale has also emerged as a doubt for the visitors, with the Wales international suffering a groin injury during the first half of the clash with Stoke in the EFL Cup.
Mourinho will make changes from the side that started against the Potters, with Serge Aurier, Toby Alderweireld, Sergio Reguilon, Moussa Sissoko, Steven Bergwijn, Tanguy Ndombele and Son Heung-min all in line to return.
Harry Kane, somewhat surprisingly, played the full 90 minutes in the EFL Cup, but there will be no rest for the England captain as he prepares to lead the attack again.
Watch the Sports Mole Football Shorts prediction for this game below: