The match marks Lennon's first appearance for the club since picking up an injury in August's home defeat to Manchester City.
Giovanni dos Santos also enters the starting XI, while former Spurs player Rohan Ricketts only makes the bench for the Turkish side.
Tottenham: Cudicini; Walker, Corluka, Bassong, Rose; Lennon, Carroll, Livermore, Giovani; Defoe, Pavlyuchenko
Subs: Gomes, Bale, Kaboul, Modric, Falque, Townsend, Kane
Shamrock Rovers: Brush; Sullivan, Sives, Murray, Rice; O'Donnell, Paterson, Dennehy, Finn; McCabe, Twigg
Subs: Thompson, Stevens, Sheppard, Kilduff, Turner, McCormack, Ricketts