Mourinho named a strong side for the first leg and was rewarded with a 2-0 win at the Tottenham Hotspur Stadium.
Harry Kane scored both goals in the reverse fixture, but he is among those that may make way here with next weekend's league clash against Aston Villa in mind.
Fellow attacker Son Heung-min has been ruled out with a hamstring injury, meanwhile, which may keep the South Korea international out of action until next month.
At the other end of the field, Joe Rodon is not part of Tottenham's travelling party as he was not included in their European squad.
Tottenham possible starting lineup: Lloris; Doherty, Sanchez, Dier, Davies; Sissoko, Winks; Lamela, Alli, Bergwijn; Vinicius