The Saints are currently bottom of the Premier League and despite their 2-0 defeat against West Bromwich Albion on Monday evening, Adkins may decide to retain Jay Rodriguez and Rickie Lambert in attack with the club in need of three points.
Goalkeeper Artur Boruc could be recalled to the starting lineup after the club decided to take no action over claims that the 32-year-old had thrown a bottle into the crowd during their 2-1 defeat to Tottenham Hotspur.
Swansea City: LLDWLD
Possible starting lineups:
Southampton: Boruc; Clyne, Yoshida, Fonte, Fox; Schneiderlin, S.Davis, Ramirez, Lallana; Lambert, Rodriguez
Swansea City: Tremmel; Williams, Monk, Rangel, Davies; Britton, Michu, Pablo, Dyer, De Guzman; Ki Sung-Yeung
Sports Mole says: 1-2