The Europa League winners were in UEFA Super Cup action on Thursday night, suffering a 2-1 defeat to Bayern Munich, while Cadiz have played twice in the league this season, picking up three points.
Cadiz secured a return to La Liga for the current season courtesy of finishing second behind Huesca in the Segunda Division last term.
The Yellow Submarine were actually regulars at this level between 1981 and 1993 but have largely been a second or third-tier side since, only playing one campaign in La Liga since the 1992-93 season.
Cadiz made a disappointing start to life back in the top flight, suffering a 2-0 defeat at home to Osasuna on September 12, which made last weekend's clash with Huesca an even bigger affair.
Sevilla, as mentioned, took on Champions League winners Bayern in the UEFA Super Cup on Thursday night, and the Spanish outfit again gave an excellent account of themselves.
Sevilla continued their rich history in the Europa League by beating Inter Milan in last season's final, while a strong La Liga campaign saw them finish fourth, which was their highest placing for three years.
Los Nervionenses have not made any particular major signings this summer in terms of transfer fee, but Suso's loan move from AC Milan has been made permanent, while Ivan Rakitic has returned to the club from Barcelona and will be determined to help secure more silverware this season.
Cadiz La Liga form: LW
Sevilla form (all competitions): L
Negredo will keep his spot at the tip of the attack following his goal against Huesca, while Pombo was also on the scoresheet last weekend and should feature on the left.
Rakitic, meanwhile, should turn out for Sevilla in La Liga for the first time since 2014, and Jules Kounde will feature in central defence despite being strongly linked with a move to Manchester City.
Cadiz possible starting lineup:
Cifuentes; Iza, Mauro, Cala, Espino; Jonsson, Mari; Pombo, Fernandez, Sanchez; Negredo
Sevilla possible starting lineup:
Vaclik; Navas, Kounde, Carlos, Acuna; Jordan, Fernando, Rakitic; Rodriguez, De Jong, Ocampos
We say: Cadiz 0-2 Sevilla
Cadiz will enter this match off the back of a positive result last weekend, but we are struggling to predict anything other than an away victory here. Sevilla have had less time to recover, but the clash with Bayern could actually help them in terms of this match, and we fancy a routine win for Lopetegui's side.