The Spanish outfit booked their spot in the final courtesy of a 2-1 victory over English giants Manchester United in the last four on Sunday night.
Inter, meanwhile, thumped Shakhtar Donetsk 5-0 to ensure that they would be present in Friday's showpiece event, which should be a fascinating affair.
Here, Sports Mole looks at how Sevilla could line up in Cologne.
Doubtful: Lucas Ocampos (knock)
Lucas Ocampos was forced off in the early stages of the second half against United, with the Argentine picking up a knock. Ocampos is expected to recover in time for Friday's final, though, which would be a huge boost for Sevilla, who could have a full complement of players available.
Experienced forward Luuk de Jong came off the bench to score the winner in the semi-final, but Youssef En-Nesyri could again get the nod from the start, with the latter again expected to feature as a substitute.
Munir El Haddadi struggled to have an impact against the Red Devils, and it would not be a surprise to see Suso again feature in a wide area, with Ever Banega, Fernando and Joan Jordan in a midfield three.
There is every chance that head coach Julen Lopetegui will select an unchanged XI if Ocampos can prove his fitness, meaning that the likes of Franco Vazquez and Oliver Torres will have to accept spots on the bench once again.
Diego Carlos - linked with the likes of Barcelona, Manchester City and Liverpool - has been the subject of transfer speculation in recent months, and the Brazilian will again be joined in the heart of the defence by Jules Kounde.