Wednesday’s Africa Cup of Nations predictions including Sadio Mane’s Senegal vs. Mohamed Salah’s Egypt

Just four teams remain in the 2025 Africa Cup of Nations and two intriguing semi-final ties take place on Wednesday.

Mohamed Salah will lock horns with his former Liverpool teammate Sadio Mane when Egypt come up against Senegal in the first semi-final showdown, before host nation and tournament favourites Morocco do battle with Nigeria.

Here, Sports Mole provides predictions for Wednesday's AFCON fixtures.

Senegal vs. Egypt (Wednesday, 5pm)

The business end of the Africa Cup of Nations is here, with Senegal and Egypt set to lock horns in Tangier on Wednesday.

Both teams have enjoyed similar results in the tournament, winning four of the five fixtures played, but the way in which they were victorious speaks volumes.

We say: Senegal 1-0 Egypt

At the moment, Senegal are operating like a well-oiled machine, while Egypt have struggled to be at their fluent best.

The Lions of Teranga have had the better of the Pharaohs in recent meetings, but the last five head-to-heads were fiercely contested contests.

While they will not run away with it, the West African side look set to book a spot in the AFCON 2025 final.

> Click here to read our full preview for Senegal vs. Egypt, including team news and predicted lineups

Nigeria vs. Morocco (Wednesday, 8pm)

Nigeria will face host nation Morocco in the semi-finals of the 2025 Africa Cup of Nations on Wednesday at the Prince Moulay Abdellah Stadium in Rabat.

This is one of the two blockbuster semi-finals, featuring some of the continent’s finest players, including recent CAF Player of the Year winners Mohamed Salah, Sadio Mane, Victor Osimhen, Ademola Lookman and Achraf Hakimi, all represented among the remaining four nations.

We say: Nigeria 3-1 Morocco

Nigeria have navigated every challenge at the tournament with authority, demonstrating depth, quality and a clear determination to make amends for the disappointment of missing out on the 2026 World Cup, with their balance across the pitch and attacking efficiency underlining why they remain such a formidable opponent.

While Morocco will be difficult to overcome with home support and the weight of expectation to finally lift the AFCON trophy, Nigeria’s relentless attacking form suggests they are unlikely to slow down, and another eye-catching display from the Super Eagles could see the West Africans spring a surprise and reach a second consecutive final.

> Click here to read our full preview for Nigeria vs. Morocco, including team news and predicted lineups