Roma currently lie fifth in the table on 48 points - level with sixth-placed Napoli, while Parma occupy 12th spot with 39 points to show from 30 matches.
Roma's dismal run of form since the restart continued on Sunday as fellow European hopefuls Napoli condemned Paulo Fonseca's side to their third defeat in succession with a 2-1 victory in Naples.
I Giallorossi have now only taken three points from a possible 12 since the Italian top flight was given the green light to resume, and their already-faint hopes of breaking into the top four are looking all the more slim at this late stage.
Roma are still ahead of Napoli in the table by means of a superior goal difference, but Fonseca's men are 15 points off the pace for a Champions League berth with eight games of the season left to play.
Fonseca's side have a mixed run of fixtures against relegation candidates and European hopefuls to contend with as the season draws to a close, and I Giallorossi will certainly be looking over their shoulder as AC Milan sit just two points adrift of the top six after a strong run of form.
Roma, however, are at risk of dropping out of the European places entirely if results do not improve soon, but they are now facing a Parma side who have endured an equally woeful run of form in the past couple of weeks.
Fiorentina ended their own winless run at Parma's expense at the weekend - with a 2-1 victory for La Viola ensuring that Parma have little to play for at this late stage of the campaign.
As is the case with Roma, Parma have only picked up one win since the restart and have lost their last three on the bounce in the Italian top flight, and the European dream for Roberto D'Aversa looks set to remain just a dream as Parma lie nine points adrift of the top six.
That is not to say that it is impossible for Parma to mount a late charge for the European places, but 13 losses is simply too many for a side with aspirations of a top-six finish, with Parma only picking up four league wins since the turn of the year.
I Crociati's recent away form has not been all that bad, though, with last week's 3-2 loss to Hellas Verona the first time that Parma had suffered defeat on the road in five matches.
Roma Serie A form: WWWLLL
Roma form (all competitions): DWWLLL
Parma Serie A form: LDWLLL
Chris Smalling was forced off early in the defeat to Napoli with a thigh problem and is set to undergo further tests this week, so it remains to be seen whether the Englishman will be available for Wednesday.
Fonseca opted for a five-at-the-back system against Gennaro Gattuso's men but is expected to revert back to his tried-and-tested 4-2-3-1 against Parma - with Bryan Cristante likely to replace Roger Ibanez.
With regards to Parma, D'Aversa's only concern is the thigh problem keeping Roberto Inglese on the treatment table, but other than that the Napoli manager has a fully fit squad to select from.
Top scorer Cornelius could return to the starting lineup after being brought on as a sub against Fiorentina, but there are not expected to be too many changes from the team at the weekend.
Roma possible starting lineup:
Lopez; Zappacosta, Mancini, Fazio, Kolarov; Cristante, Veretout; Mkhitaryan, Pellegrini, Kluivert; Dzeko
Parma possible starting lineup:
Sepe; Darmian, Iacoponi, Alves, Gagliolo; Kukca, Scozzarella, Kurtic; Kulusevski, Cornelius, Gervinho
We say: Roma 2-1 Parma
The two clubs will be determined to end their respective winless runs on Wednesday, and both will no doubt believe that they are equally capable of coming out trumps in this game. That being said, we expect the superior quality of Roma to pull through and give the home side a narrow victory as they endeavour to keep their European hopes alive.