Marco Carvalho's men picked up a point away from home against league-leaders Sporting Lisbon last time out, while the visitors fell to a disappointing defeat on home soil when they entertained Famalicao.
Rio Ave are currently 10th in the league standings after picking up 15 points from their opening 14 league games.
The Portuguese top flight is extremely tight this year, and despite Carvalho's side's respectable position, they are only three points above the relegation zone.
Scoring goals has been the Estadio dos Arcos outfit's issue throughout 2020-21. They have found the back of the net on just 10 occasions to date, meaning only one Primeira Liga side has scored fewer goals than Vilacondenses.
A clash on home soil against a team just one place above them is a perfect opportunity for Rio Ave to put some daylight between themselves and the drop zone, and that is exactly how they will be viewing this midweek encounter.
If Carvalho can harness the momentum of his side's promising performance last time out, then the three points could be theirs.
Daniel Ramos's side have failed to pick up three points while on Primeira Liga duty since the start of December, and their recent struggles are threatening to drag them back into the relegation mix.
Two points from a possible 15 represents a serious slump for Os Acoreanos, who made a strong start to the season, and they will be desperate to turn their fortunes around as quickly as possible.
Brazilian forward Thiago Santana was crucial to Santa Clara at the start of the campaign, scoring seven top-flight goals in nine Primeira Liga appearances, and his transfer to J-League outfit Shimizu S-Pulse has hugely affected his former club's form.
Rio Ave Primeira Liga form: DLLLWD
Rio Ave form (all competitions): LLLWLD
Santa Clara Primeira Liga form: WLLDDL
Santa Clara form (all competitions): LLDDWL
Rio Ave will be without a number of first-team players due to injury and suspension. Right-back Junio is a long-term absentee after the young defender broke his leg back in June.
Ramos has the luxury of a fully-fit squad to choose from on Monday in what could prove to be a pivotal game in Santa Clara's season.
That means Iranian striker Shahriar Moghanlou is set to start up front once again as the 26-year-old searches for his first goal of the season.
Rio Ave possible starting lineup:
Kieszek; Coentrao, Santos, Borevkovic, Pinto; Guga, Tarantini; Amaral, Chico Geraldes, Carlos Mane; Gelson
Santa Clara possible starting lineup:
Marco; Ramos, Cardoso, Villanueva, Lucas; Carvalho, Nene; Carlos, Lincoln, Ukra; Moghanlou
We say: Rio Ave 1-1 Santa Clara
Neither side are in great form coming into this one and will be happy to take home a point apiece. We think it is most likely to end in a low-scoring draw after a game of few chances between two evenly matched teams.