With Gareth Bale's enforced absence from the squad, Zidane instead turns to Asensio - a second-half sub in the 1-1 draw against Tottenham Hotspur here last time out - to link up with attacking midfielder Isco and leading marksman Ronaldo in attack.
Nacho is utilised in the backline once again, meanwhile, with Dani Carvajal continuing to miss out with a heart problem, but Raphael Varane has shaken off an injury concern to start alongside Sergio Ramos in the heart of defence.
There is also a starting spot for Kiko Casilla, as confirmed earlier in the week, with first-choice stopper Keylor Navas nursing an adductor injury that will likely keep him out for two weeks - one of five changes from that Tottenham draw.
Charles and Takashi Inui are used from the off, meanwhile, coming in for Sergi Enrich and Kike as Los Armeros aim to build on a run that has seen them score just three times in their first eight games.
Real Madrid: Casilla; Nacho, Varane, Ramos, Theo Hernandez; Casemiro, Modric, Ceballos; Isco, Asensio, Cristiano Ronaldo
Subs: Moha, Kroos, Benzema, Marcelo, Lucas, Llorente, Achraf
Eibar: Dmitrovic; Capa, Paulo Oliveira, Lomban, Jose Angel; Arbilla, Rivera, Escalante, Jordan; Charles, Inui
Subs: Riesgo, Galvez, Enrich, Bebe, Pena, Kike, Junca
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