Los Blancos are tied with Barcelona at the top of the table entering the match, which serves as Real's game in hand ahead of this weekend's final round of fixtures.
Celta, meanwhile, have made seven changes to the XI which fell to a 3-1 defeat at Alaves on Sunday.
Celta Vigo: Sergio, Mallo, Cabral, Roncaglia, Jonny, Hernandez, Jozabed, Wass, Aspas, Sisto, Guidetti
Subs: Villar, Fontas, Pape, Diaz, Beauve, Hjulsager, Gomez
Real Madrid: Navas, Danilo, Varane, Ramos, Marcelo, Kroos, Casemiro, Modric, Isco, Benzema, Ronaldo
Subs: Casilla, Nacho, Coentrao, Kovacic, Vazquez, Asensio, Morata
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