The hosts were halted on their six-match winning streak by Real Zaragoza, who held them to a 1-1 draw at the weekend.
On the same day, Levante beat Sevilla 1-0, which was their first victory in eight league games, a run that went back to the end of January.
Jose Mourinho has a full squad at his disposal, but could make a couple of changes to his side from the win against Galatasaray.
Possible starting lineups
Real: Lopez; Arbeloa, Ramos, Varane, Coentrao; Alonso, Khedira; Di Maria, Ozil, Ronaldo; Higuain
Levante: Munua; Lell, Vyntra, Rodas, Juanfran; Iborra, Diop; Rios, Michel, Ruben; Acquafresca
Sports Mole says: 3-1